Daflon 1000 . For Heavy, Painful legs and Varicose Veins

Recommended, non prescription brand for treating chronic venous insufficiency symptoms. 1

How does Daflon 1000 work?

wave icon

Venoactive treatments, like Daflon 1000 , are designed to help improve our leg vein health by strengthening the tone of our veins, which continue to weaken as chronic venous insufficiency progresses.

Daflon 1000 has a dual mechanism of action; it's anti-inflammatory action venoprotective directly reduces pain and swelling; it also protects the capillaries or tiny blood vessels to improve microcirculation and venous tone for better vein health and relief of symptoms such as leg pain, and swelling. 2

Daflon 1000 is available in all pharmacies

Tackle leg pain from the inside

wave icon

Daflon 1000 is a clinically proven, effective and convenient oral treatment derived from immature oranges and specially formulated for maximum absorption. 2

This improved absorption means Daflon 1000 can get to the root of the problem and effectively treat veins from the inside, improving the tone of veins, potentially protecting against disease progression and providing relief from heavy, painful leg symptoms. 2

Demonstrated effect of Daflon Over 8 weeks

4 weeks 4

8 weeks 4

Leg pain

50%

63%

Sensation of heaviness

50%

65%

Sensation of swelling

50%

63%

Relieves Symptoms

wave icon

Daflon 1000 is the # 1 doctor recommended, non prescription brand for treating the symptoms of chronic venous insufficiency. 1

Clinical Studies have shown that Daflon 1000 can reduce leg pain and the sensations of heaviness and swelling by up to 50% after only one month of use. These figures were even higher after two months of treatment.

To benefit from your Daflon treatment, you should take your medication as recommended. Be sure to monitor your condition closely and speak with a health care professional if you have any concerns.

Naturally sourced, scientifically prepared.

wave icon

The active ingredient in Daflon 1000 is a micronized purified flavonoid fraction (MPFF)6 containing 90% diosmin and 10% other flavonoids expressed as hesperidin.

Daflon’s flavonoids are extracted from immature oranges that are rich in these naturally occurring plant chemicals. The compounds undergo a process of purification and refinement where the particles are made to collide with each other at high speeds (micronization), reducing them to tiny particles, less than 2 μm in size (micronized). These smaller particles are absorbed twice as easily by the body and are a key ingredient of Daflon’s success as a treatment for improving vein health and tone in Chronic Venous Insufficiency and Hemorrhoids. 6

Safety Information:

Daflon 1000 mg Safety Information

"Daflon 1000: Micronised, purified flavonoic fraction 1000 mg quantity corresponding to: Diosmin 90 % 900 mg Flavonoids expressed as hesperidin 10 % 100 mg Average moisture content 40 mg per film-coated tablet. INDICATIONS It is recommended for treating venous circulation disorders (swollen legs, pain, restless legs) and symptoms due to acute hemorrhoidal attack. If the haemorrhoidal episodes persist for more than 15 days, it is essential that you consult your doctor. It is indicated in the treatment of functional menorrhagia and premenstrual syndrome.DOSAGE AND ADMINISTRATION Always take DAFLON 1000 mg exactly as your doctor has described. If you are not sure, you should check with your doctor or pharmacist. The usual dose is 1 tablet daily at mealtimes. If you take this medicine for a haemorrhoidal episode, the usual dose is 3 tablets per day for 4 days and then 2 tablets per day for the next 3 days at mealtimes.

CONTRAINDICATIONS If you are allergic (hypersensitive) to micronised purified flavonoid fraction, especially diosmin (or hesperidin), or any of the other ingredients in this medicine. WARNINGS Warning and precautions Ask your doctor or pharmacist before taking Daflon 1000 mg, film coated tablet. Children Not applicable. Taking or using other medicines with Daflon 1000 mg, film-coated tablet Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Taking Daflon 1000 mg, film-coated tablet with food and drinks Not applicable Pregnancy and breastfeeding Pregnancy If you become pregnant during your treatment, or if you are pregnant and plan to take this medicine, ask your doctor or your pharmacist for advice. Breast feeding : Breast-feeding is inadvisable for the duration of the treatment, due to the absence of data on the passage of the medicine into breast milk. Ask your doctor or pharmacist for advice before taking any medicine. Sports Not applicable Driving and using machines Not applicable Excipients: Sodium starch glycolate, microcrystalline cellulose, gelatine, magnesium stearate, talc. Film coating: Titanium dioxide (E 171), glycerol, sodium laurylsulphate, macrogol 6000, hypromellose, yellow iron oxide (E 172), red iron oxide (E 172), magnesium stearate.

possible side effects Common: diarrhoea, dyspepsia, nausea, vomiting. Uncommon: colitis.Rare: dizziness, headache, malaise, rash, pruritus, urticaria. Not known frequency: abdominal pain, isolated face, lip, eyelid oedema. Exceptionally Quincke's oedema If you take more Daflon 1000 mg, film-coated tablet, than you should: Consult immediately your doctor or pharmacist. An overdosage of this medicine can make side effects worse. PROPERTIES* Pharmacotherapeutic class: VASCULOPROTECTORS/ MEDICINES ACTING ON CAPILLARIES/ BIOFLAVONOIDS This medicine is a venotonic (it increases venous tone) and a vasculoprotector (it increases resistance in small blood vessels). to report Suspected Adverse Drug Reaction kindly fill attached form

المراجع:

1. IQVIA Daflon sales data MAT Q2 2021 2. Adapted from Nicolaides A, Kakkos S, Baekgaard N, et al. Management of chronic venous disorders of the lower limbs. Guidelines according to scientific evidence. Part I. Int Angiol. 2018;37(3):181-254.1 3. Garner RC, Garner JV, Gregory S, Whattam M, Calam A, Leong D. Comparison of the absorption of micronized (Daflon 500 mg) and nonmicronized 14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting. J Pharm Sci. 2002;91:32-40. 4. Gilly R, Pillion G, Frileux C. Evaluation of a new venoactive micronized flavonoid fraction (S 5682) in symptomatic disturbances of the venolymphatic circulation of the lower limb: a double-blind, placebo-controlled study. Phlebology. 1994;9:67-70. 5. Pascarella L, Lulic D, Penn AH, et al. Mechanisms in experimental venous valve failure and their modification by Daflon 500 mg. Eur J Vasc Endovasc Surg. 2008;35(1):102-110. 6. Summary of Product Characteristics Daflon

2024